Abstract :
Background: Helicobacter pylori is a spiral gram negative bacteria etiologically linked to several medical conditions. More than one half of world’s populations had been infected, particularly in developing countries.Recently, The Fujinon Intelligent Chromo Endoscopy (FICE), which demonstrated the regular arrangement of collecting venules patterns (RAC), is a new modality to diagnose H. pylori infection. The objective of this study is to determine the accuracy of the arrangement of collecting venules pattern for diagnosis of H. pylori infection.
Patients and Methods: Fifty eight patients with dyspepsia were evaluated by esophagogastroduodenoscopy(EGD) and FICE. The images of collecting venules pattern were recorded at the fundus and lesser curvature. Additionally, the gastric biopsies were obtained. The presence of H. pylori infection was determined by rapid urease test or histology. The sensitivity and specificity of the collecting venules pattern in diagnosis of H. pylori infection was evaluated.
Results: H. pylori was detected in 28 patients (48%). The RAC negative pattern provided 89.2% sensitivity and 70% specificity in diagnosis of H. pylori infection in patients with dyspepsia. The negative predictive value (NPV) and the positive predictive value (PPV) were 87.5% and 73.5% respectively. In addition, the overall validity was 79.3%.
Conclusion: The abnormal arrangement of collecting venules near incisura angularis of the stomach
provided the acceptable sensitivity and negative predictive value in diagnosis of H. pylori infection in patients with
dyspepsia. It could be used as a screening test for H. pylori infected gastric mucosa. |
file/Thai-Journal-of-gastroenterology-vol-13-no-2-3624438.pdf