Objectives: To estimate the prevalence of insulin resistance (IR) among Thai chronic hepatitis C patients
with various HCV genotype.
Methods: Twenty seven patients met the conditions for enrollment. Insulin resistance was determined
with the homeostasis model assessment insulin resistance (HOMA-IR) equation, defined IR by HOMA-IR ≥ 2. The
degree of necroinflammatory activity, and steatosis as well as fibrosis stage in liver biopsy specimens were scored.
The data analyzed with SPSS 11.5 for Windows.
Results: The prevalence of IR as defined by HOMA-IR ≥ 2 was 77.8% (21/27) among patients with
HCV infection. Eighty-eight percent of HCV genotype 1 patients and 71.4% of HCV genotype 3 patients had IR.
Conclusion: The prevalence of insulin resistance in HCV infected patients in this study was 77.8%,
and it was more common in genotype 1. No significant difference was found between insulin resistance and hepatic
steatosis, or hepatic fibrosis in HCV infected patients.