Abstract :
Aim: To assess possible associated factors for fatty pancreas (FP) in an Asian population at a tertiary care hospital.
Methods: We prospectively collected relevant clinical data of consecutive patients who had undergone abdominal computed tomography (CT) in King Chulalongkorn Memorial Hospital, Bangkok, Thailand from Au- gust to November 2015. Criteria of CT were used for diagnosis of FP which is defined by presence lower attenua- tion more than 5 compare with spleen.
Results: Four-hundred-twenty-eight consecutive patients were enrolled. Sixteen (3.7%) were excluded due to pancreatic cancer (n=6), pancreatitis (n=6) and post splenectomy (n=4). The remaining 412 patients (182 M, 230 F, mean age 60.7±13.3 years) were recruited for analysis. Indications for abdominal CT were non-pancreatic cancer (n=310) and non-cancer (n=102). The prevalence of FP was 40.5%. On uni-variate analysis, significantly associated factors were impaired fasting plasma glucose (Odds Ratio (OR) 1.71, 95% CI 1.08-2.69, p=0.02) and fatty liver (OR 4.94, 95% CI 2.75-8.88, p=0.01). By using multivariate analysis, the independent associated risk factors of FP were impaired fasting blood glucose (OR 1.08, p=0.04) and fatty liver (OR 1.608, p= 0.01). Interest- ingly, the prevalence of FP in patients with previous exposure to systemic chemotherapy increased from 30% to 40% (mean follow-up time 6 months, p=0.01).
Conclusion: In this study, an Asian population, fatty liver and impaired fasting plasma glucose were strongly associated with FP. Systemic chemotherapy appeared to increase the prevalence of FP. Future study is required to confirm the degree of association and its clinical implication. |
file/Thai-Journal-of-gastroenterology-vol-17-no-3-3454465.pdf