Abstract :
Objectives: Good bowel preparation quality helps gastroenterologists to carry out colonoscopy easier. However, bowel preparation quality for colonoscopy is sometimes not good enough. Moreover, a large volume of fluid needed for bowel preparation is frequently troublesome for the patient. We studied the effect of domperidone in improving bowel preparation quality and in reducing unpleasant symptoms.
Methods: We randomly assigned patients into two groups to receive either polyethylene glycol plus domperidone 10 mg three times before meal on the day prior to colonoscopy or polyethylene glycol alone. The primary endpoint was bowel cleansing level at different parts of the colon. The secondary endpoint was occurrence of unpleasant symptoms from bowel preparation.
Results: Administration of domperidone prior to colonoscopy significantly led to more acceptable bowel cleansing quality at the caecum (60.1% in the domperidone group vs. 32.1% in the control group, p<0.001), at the transverse colon (85% vs. 58.3%, p<0.001) and at the sigmoid colon (91.3 vs. 83.3%, p=0.026). Unpleasant symptoms from bowel preparation also decreased in the domperidone arm.
Conclusion: Addition of domperidone to polyethylene glycol for bowel preparation for colonoscopy can improve bowel cleansing quality and decrease the occurrence of unpleasant symptoms from bowel preparation.
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file/Thai-Journal-of-gastroenterology-vol-15-no-2-4735423.pdf