Abstract :
Background & Aims: Cholangiocarcinoma (CCA) is the common cause of biliary tract obstruction in
Thailand. The objective of this study is to analyze the characteristics and outcomes of endoscopic drainage for CCA
in the Southern part of Thailand.
Methods: A retrospective analysis of a prospectively recorded ERCP database of patients with
unresectable CCA underwent plastic stent insertion the NKC institute, Songklanakarind Hospital from 2008-2011.
CCA was diagnosed by clinical data or histology. The demographic data, endoscopic success rate, clinical response
rate, complications and survival were collected and analyzed.
Results: Seventy two patients (34 males, and 38 females) with a mean age ± SD of 63.6±13.3 years
were recruited. Endoscopic success was obtained in 69 of 72 patients (95.8%), clinical success drainage was achieved
in 39 of 51 evaluable cases (76.4%) with 34 required one ERCP session and 5 required 2 ERCP sessions. The
clinical success rate in hilar CCA (HCCA) and distal CCA (DCCA) was similar. The complication rate was comparable
to other reports. The overall median survival time was 112 days (95% CI = 74-169), with the cumulative 3
month, 6 month 1 year survival rates of 55.2%, 34.3% and, 12.7% respectively. The median survival time in HCCA
was 93 days (95% CI 61-169) and in DCCA was 164 days (95% CI 46-NA) (p >0.05). The median survival time of
successful drainage cases was 165 days (95% CI 115-272) compared with unsuccessful drainage cases was 14 days
(95% CI 4-NA) (p <0.05).
Conclusion: The demographic data in this study are showed equal frequency in both genders whereas
another reports showed male predominant. The endoscopic drainage and clinical success rates in this study are
higher and the median survival time is longer compared with another study in the similar endoscopic drainage. |
file/Thai-Journal-of-gastroenterology-vol-14-no-3-2845412.pdf