Abstract :
Background: The pathophysiologic mechanism involved in non-ulcer dyspepsia (NUD) is largely unknown.
One hypothesis concerns eosinophilia-mediated hypersensitivity. A Swedish study reported that NUD was
associated with duodenal eosinophilia. In Thailand, data on duodenal eosinophilia in Thai NUD patients has not
been documented.
Aim: To evaluate an association between duodenal eosinophilia and NUD in Thai patients.
Patients and Methods: Thirty-five NUD patients and 7 control subjects underwent gastroduodenoscopy
with biopsy specimens each from the body of stomach, antrum, duodenal bulb and second part duodenum. Eosinophilic
counts were assessed for each biopsy specimen by summation of microscopic counting over 5 high-power
fields. Another biopsy specimen from the gastric antrum was also obtained for the rapid urease test.
Results: Thirty-five patients were enrolled in the NUD group, 10 males (28.5%) and 25 females (71.5%),
with a median age of 46 (20-69) years. There were 7 subjects in the control group, 2 males (28.6%) and 5 females
(71.4%) with a median age of 65 (33-75) years. There were 2 subjects with gastric ulcer, 3 subjects with erosive
gastritis and 2 subjects with severe hemorrhagic gastritis. Over 90% of NUD patients had intermittent dyspeptic
symptom(s) for more than 12 weeks. Most patients in both groups had mild to moderately severe of epigastric pain,
abdominal bloating and postprandial fullness. Helicobacter pylori infection was found in 28.6% to 45.2%, with no
correlation to any dyspeptic symptoms. The median duodenal eosinophilic counts in the NUD group and in the
control group were 7.5 (0-34) cells/5 HPF and 8.0 (4-21) cells/5 HPF, respectively. The difference was no statistical
significance.
Conclusion: In this study, there was no association between duodenal eosinophilia and NUD in Thai
patients. |
file/Thai-Journal-of-gastroenterology-vol-11-no-1-1760389.pdf