Abstract :
Albumin is a small protein circulating between the intravascular and extravascular spaces. Serum albumin level is a strong predictor of morbidity and mortality in critically ill and post-operative patients. The superiority of colloids (albumin, etc.) over crystalloids with regard to fluid resuscitation in critical conditions has not been confirmed. The formation of ascites in cirrhosis is due to elevated hydrostatic pressure related to portal hypertension and reduced oncotic pressure from hypoalbuminemia. Albumin infusion prevents post-circulatory dysfunction after large-volume paracentesis. Albumin administration during spontaneous bacterial peritonitis prevents the progression to hepatorenal syndrome and reduces mortality. Several studies of hepatorenal syndrome showed that albumin treatment combined with vasoconstrictors improved renal function markedly, leading to improved postliver transplant survival and renal function.
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file/Thai-Journal-of-gastroenterology-vol-10-no-2-1767489.pdf