Abstract :
Background:
Nowadays the treatment of chronic constipation has been far from satisfaction. Sodium
Patients and Methods:
were included. Enrolled subjects were randomly assigned to treatment with NaP solution 10 or 20 cc.
daily for 28 days. Patients recorded their bowel movements and associated symptoms on daily basis. Vital signs
and blood chemistry were assessed weekly.
According to ROME III criteria, adult ambulatory patients with chronic constipation
Results:
(group 1) and 9 patients to 20 cc. NaP solution (group 2). Treatment success was ranging from 50% to 71% in
group 1 and 100% in group 2. No patient in group 1 but 8 of 9 patients in group 2 developed watery stool. No
patient had serious adverse event in both groups. Two patients in group 2 developed mild hypokalemia and hypocalcemia.
Meanwhile, in treatment group, no one had postural hypotension, renal insufficiency or hypophosphatemia.
Seventeen patients were enrolled. Eight patients were assigned to receive 10 cc. NaP solution
Conclusion:
stool in most cases. NaP solution 10 cc. seemed reasonable for further study about its efficacy and safety for a
constipation patient.
NaP solution 20 cc. was effective to increase bowel movement with evidence of watery
Phosphate (NaP) solution has been used for a long time as effective colorectal cleansing. This study aims to define
dosing of NaP solution in patient with chronic constipation. |
file/Thai-Journal-of-gastroenterology-vol-10-no-1-3981208.pdf