Abstract :
Background: Curcumin, a major constituent of tumeric powder, is renowned for its anti-inflammatory effect but the studies of its effects on nonsteroidal anti-inflammatory drugs (NSAIDs)-induced gastropathy are still limited.
Aims: To investigate the gastroprotective effect of curcumin on NSAIDs-induced acute mucosal injury and its influence on plasma tumor necrosis factor (TNF)-? level.
Methods: Male Sprague-Dawley rats, weighing 200-250 g, were randomly divided into 4 experimental groups of five rats. Group 1 (Control): Sterile water was given. Group 2: Indomethacin (100 mg/kg) was given. Group 3: Indomethacin (100 mg/kg) and curcumin (60 mg/kg) were given. Group 4: Indomethacin (100 mg/kg) and curcumin (200 mg/kg) were given. In groups 3 and 4, indomethacin was given at 30 minutes after curcumin administration. Four hours after sterile water or indomethacin administration, blood samples for the TNF assay were withdrawn. The stomach was then removed to study gastric histopathology. Serum level of TNF-? was determined using ELISA method.
Results: Pretreatment with curcumin (60mg/kg) at 30 minutes before administration of indomethacin resulted in a decrease in mean gastric erosion score (p <0.05). In addition, there was a statistically significant difference on gastric erosion score between group 2 and group 4 (p <0.001). However, there was no significant difference on TNF-? level among the four groups.
Conclusion: Curcumin accomplishes the protective effect on NSAIDs-induced gastric mucosal injury in a dose dependent manner without affecting serum TNF-a level. |
file/Thai-Journal-of-gastroenterology-vol-9-no-3-520417.pdf