Abstract :
Background:
Perinuclear antineutrophil cytoplasmic antibodies (pANCA) are the well recognized
Objective:
patients.
To assess the value of using pANCA and/or ASCA for the diagnosis of adult Thai IBD
Methods:
of both seromarkers was performed by using the standardized indirect immunofluorescence technique in all sera.
Serum sample were obtained from 19 patients of CD and 50 patients of UC. Determination
Results:
specificity of 16.0%, 89.5% respectively for UC. The combination of a negative pANCA test and a positive ASCA
test yielded a sensitivity and specificity of 42.1%, 62.0% respectively for CD. There was no correlation between
the positively of both seromarkers and the clinical features of both diseases.
The combination of a positive pANCA test and a negative ASCA test yielded a sensitivity and
Conclusion:
population. ASCA and pANCA are not useful diagnostic tools for differentiating UC from CD in adult Thai
patients compare with Western population.
The prevalence of pANCA in Thai UC patients is much lower than that in the Western
marker for ulcerative colitis (UC). Antibodies to oligomannosidic epitopes of yeast Saccharomyces cerevisiae
(ASCA) are the new seromarker associated with Crohn’s disease (CD). While the prevalence of both UC and CD
in Thai populations is low, it is interesting to know the role of these seromarkers in such population. |
file/Thai-Journal-of-gastroenterology-vol-9-no-3-277416.pdf