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Thai Journal of Gastroenterology
2007 Vol.8 No.3
Article :
Immunochemical Fecal Occult Blood Testing for Early
Gastrointestinal Bleeding Detection in Patients Using Warfarin |
Author :
Prasongsuksan P,M.D.
Prasongsuksan C,M.D. |
Abstract :
Background:
arfarin is an effective drug for treatment and prevention of thromboembolic disorders; however,acute gastrointestinal bleeding is a life-threatening complication of warfarin therapy.Immunochemical fecal occult blood testing is widely recommended as a screening test for occult gastrointestinal bleeding.Thus we used the immunochemical fecal occult blood testing to early detect gastrointestinal bleeding in patients using warfarin.
Objective:
To determine the role of immunochemical fecal occult blood testing for detection of gas-trointestinal bleeding in patients who are on warfarin treatment.
Patients and Methods:
22 patients who have indications to be on warfarin were enrolled in this study, FOBT was tested before and followed up during warfarin-fecal occult blood protocol.All patients that fecal occult blood test was positive underwent esophagogastroduodenoscopy (EGD).Colonoscopy was performed in patient with a negative EGD.
Results:
4 of 22 patients had positive fecal occult blood testing positive,3 of 4 patients have positive EGD finding;one patients had gastric ulcer,two had haemorrhagic gastritis.One of 4 patients had colonoscope, which findings revealed diverticulitis.Fecal occult blood testing was negative in 18 of 22 patients.No patients developed overt gastrointestinal bleeding and still had fecal occult blood testing negative at the end of study.
Conclusion:
This is the first study of immunochemical fecal occult blood testing for detection of gastrointestinal bleeding under warfarin.The result showed that immunochemical fecal occult blood testing may have benefit for early detection of gastrointestinal bleeding under warfarin. |
Keyword :
Immunochemical Fecal Occult Blood Testing,Gastrointestinal Bleeding,arfarin
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file/Thai-Journal-of-gastroenterology-vol-8-no-3-2077267.pdf