Abstract :
Background:
Hepatitis B is a common cause of liver disease in South East Asia.The major route of the transmission is perinatal.It is controversial whether or not an adverse pregnancy outcome is related to the hepatitis B antigenemic status (HBsAg positivity).
Objective:
To determine relationship between maternal HBsAg positivity and pregnancy outcomes
Patients and Method:
A retrospective case control study was conducted.Patient ’s data were collected from the medical records of the antenatal clinics of both the out-patients and in-patient departments.Data of 164 HBsAg positive and HBsAg negative pregnant women (age and date of delivery matched)were compared.
Results:
The overall incidence of HBsAg positivity was 1.93%at the Thai Army Hospital between 1 January 2003 and 31 December 2005.HBeAg was decremented in 103 persons,40 being HBeAg positive and 63 HBeAg negative.The data of healthy HBsAg positive pregnant women,20-39 years of age,were compared with those of HBsAg negative pregnancy cases.There were no significant differences in the general demographic data, pregnancy outcomes (e.g.,preterm labor,gestational hypertension,gestational diabetes mellitus,postpartum hemorrhage)and perinatal outcomes (e.g.,intrauterine growth retardation,oligohydramnios,preterm birth,fetal distress,chorioamniitis).
Conclusions:
There was no relationship between HBsAg positivity and pregnancy outcomes.The presence of HBsAg in pregnant women does not pose an additional risk for the pregnancy and perinatal complications.
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file/Thai-Journal-of-gastroenterology-vol-8-no-3-726235.pdf