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Thai Journal of Gastroenterology
2007 Vol.8 No.3
Article :
Effect of Prior use of Omeprazole on the Result of Urea Breath Test for the Detection of Helicobacter pylori Infection |
Author :
Thongbai T,M.D.
Thong-Ngam D,M.D.
Mahachai V,M.D.
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Abstract :
Background:
Use of a proton pump inhibitor may be associated with a false-negative result for
Helicobacter pylori
13C-UBT
detection using 13C-UBT.In this study the effect of prior use of omeprazole on results was evaluated.
Methods:
A total of 36 dyspeptic patients who tested positive for H.pylori infection by the rapid urease test were enrolled.Baseline 13C-UBT was performed on day 0.All patients received omeprazole 20 mg/day for 14 days.The 13C-UBT was performed on day 14,and was repeated one week later (day 21)in those patients who tested negative on day 14.
Results:
and 28 female (78%)patients completed the study.Five (13.9%)of thirty six patients had negative
Thirty-six patients were enrolled,the mean age being 47 ±13.23 yrs.A total of 8 male (22%)
13C-UBT
while receiving omeprazole at day 14 although they did not receive eradication therapy,implying false negative results. These five patients tested positive for 13C-UBT after 7 days of discontinuing omeprazole.
Conclusions:
Prior treatment with omeprazole 20 mg/day led to a false-negative 13C-UBT in 13.9%of case.This effect resolved after 7 days of discontinuation of omeprazole.The result of this study suggested that prior use of omeprazole resulted in a 13.9% false negative rate of 13C-UBT ,and that omeprazole should be with held at least one week prior to testing to avoid a false negative result. |
Keyword :
Helicobacter pylori ,Omeprazole,Urea breath test
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file/Thai-Journal-of-gastroenterology-vol-8-no-3-414290.pdf