Abstract :
Background:
There is an increase in prevalence of hepatic steatosis in chronic viral hepatitis B and C.
Aim:
resistance.
To determine an association of hepatic steatosis with cytochrome P450 2E1 activity and insulin
Methods:
without steatosis determined by liver histopathology. All patients were admitted for a liver biopsy before starting
treatment for chronic viral hepatitis.
We compared cytochrome P450 2E1 activity and insulin resistance between patients with and
Results:
of our patients had metabolic syndrome. The mean body mass index was 22.84 ± 2.90 kg/m
chronic hepatitis B and thirty-six percent of chronic hepatitis C had steatosis in liver histopathology. There was no
difference in cytochrome P450 2E1 activity and insulin resistance between the patients with and without hepatic
steatosis nor between hepatitis B and C. There was also no significant difference in HAI score and fibrosis score of
liver tissue between patients with and without hepatic steatosis.
Nineteen cases of chronic hepatitis B and 25 cases of chronic hepatitis C joined our study. None2. Forty-two percent of
Conclusions:
steatosis in patients who had low risk of metabolic syndrome. However, liver histopathology had a dynamic
process. Cross-sectional study may not entirely explain the pathogenesis of hepatic steatosis in chronic viral hepatitis.
The cytochrome P450 2E1 activity and insulin resistance may not be associated with hepatic
[Thai J Gastroenterol 2007; 8(2): 65-72]
There were reports that hepatic steatosis impaired response of chronic hepatitis C treatment and developed more
fibrosis. Insulin resistance was reported to be associated with hepatic steatosis. Cytochrome P450 2E1 also had
shown some associations with steatosis of liver tissue in in vitro study. |
file/Thai-Journal-of-gastroenterology-vol-8-no-2-274274.pdf