There are many factors related to alcoholic liver disease pathology which contribute to disease model development. First, modification of liver metabolism (i.e. storing of lipids and decreasing of essential nutrients) and increased hepatotoxicity of ethanol by formation of reactive oxygen species. Second, stimulation of innate inflammatory immune responses and kupffer cell which related to induction of proinflammatory cytokines. Finally, elevation of liver injury resulting from continued inflammatory immune responses bringing about activation of stellate cell which produces collagen within the liver(1).
Key words : Animal model, alcohol, liver injury