Abstract :
Background: Current knowledge suggests that pathogenesis of autoimmune hepatitis (AIH) may be
environmental triggering e.g. viral, or drugs in a genetically susceptible host. Defining the genetic basis of the
disease is a major challenges to expand the understanding of the disease.
Aim: To investigate the association between AIH type I and HLA class II alleles in Thai patients.
Patients and Methods: We analyzed data of 56 AIH patients and collected blood for Human leucocyte
Antigen (HLA) class II analysis in 42 patients who have attended Siriraj Hepatitis Clinic between January 1990 to
October 2003. Data included clinical presentations, laboratory results, and liver histology. Serological typing and
class II genotyping were performed using the polymerase chain reaction (PCR-SSOP) methods.
Results: The HLA DRB1*0301, and DQA1*0101 were significantly associated with AIH patients when
2 2
compared to controls; [OR = 3.92 (1.18-13.30), ? = 5.28, p value 0.021, OR = 2.31 (1.13-4.73), ? = 5.43, p value
0.019, respectively]. When considering only 18 patients with “definite” AIH, only HLA DRB1*0301 was signifi-
2
cantly associated with the disease (OR = 5.22, 95%CI = 1.28-20.92, ? = 5.87, p value 0.015)
Conclusion: DQA1*0101 and, particularly HLA DRB1*0301 were significantly associated with AIH in
Thailand.
[Thai J Gastroenterol 2004; 5(3): 161-166] |
file/Thai-Journal-of-gastroenterology-vol-5-no-3-2374436.pdf