Abstract :
Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most commonly prescribed
drugs worldwide. The mechanisms of NSAIDs induced gastrointestinal injury are multifactors. Curcumin
is isolated from the rhizomes of the plant Curcuma longa. They are known anti-inflammatory properties.
Objective: The aim of this study was to investigate the effects of curcumin on gastric microcirculation
and anti-inflammation action on rats with NSAIDs induced gastric injury.
Methods: Male Spraque-Dawley rats were randomly divided into three groups. Control group was fed
olive oil and 5% NaHCO3
– (vehicle). Group 2 (NSAIDs) was fed olive oil and indomethacin 150 mg/kg BW
dissolve in 5% NaHCO3
– at time 0th, 4th hr. Group 3 was fed curcumin 200 mg/kg BW dissolved in olive oil 0.5 ml
30 minute prior to indomethacin 150 mg/kg BW in 5% NaHCO3
– at 0th, 4th hr. Leukocyte-endothelium interaction
at postcapillary venule were record after acridine orange injection. Finally, the stomach was removed for histopathology
grading for gastric mucosal injury.
Results: In NSAIDs group, the leukocyte adherence in postcapillary venule was significantly increased
when compared to the control group (6.66 ± 2.33 vs 1.33 ± 0.20 cells/field, p <0.001). And pretreatment with
curcumin group, leukocyte adherence was reduced significantly compared to NSAIDs group (1.97 ± 0.30 vs 6.66 ±
2.33 cells/field, p <0.001). In the NSAIDs group, the histopathology of stomach showed damaged with mild to
severe mucosal inflammation and gastric lesions were erosive and ulcerative. In pretreatment with curcumin improved
the stomach histopathology that showed only mild gastric mucosal injury and reduced erosive lesion of
gastric mucosa.
Conclusion: Curcumin accomplishes the protective effect on NSAIDs-induced gastric mucosal injury.
Pretreatment with curcumin could improve the leukocyte adherence in postcapillary venule and improve the gastric
histopathology. |
file/Thai-Journal-of-gastroenterology-vol-11-no-1-4232392.pdf